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Kevin Stachelek


· Ph.D Candidate, University of Southern California
· stchlk.rbind.io ·
orcidID · Github · bluesky
Last updated on 2022-10-26


I am a student in the USC PIBBS Cancer Biology and genomics program mentored in the lab of Dr. David Cobrinik. My career aspiration is to lead a bioinformatics research group in industry or academia facilitating genomic analysis for research and clinical applications.

Education

PhD Candidate, Cancer Biology and Genomics

University of Southern California, Los Angeles, CA

hideme

2018 —

M.S. Translational Biotechnology

University of Southern California, Los Angeles, CA

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2015 — 2018

B.A. Biology

University of Southern California, Los Angeles, CA

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2009 — 2013

Professional Experience

Graduate Student Researcher

University of Southern California
PI: David Cobrinik

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2018 —

Technician

Children’s Hospital Los Angeles
PI: David Cobrinik

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2013 — 2018

Undergraduate Research Assistant

University of Southern California
PI: John Tower

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2012 — 2013

Grant Support

St. Baldrick’s

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2019 — 2020

Scholarships and Awards

Undergraduate SOAR

hideme

2013

Peer-reviewed Publications

Li, H.-T., Xu, L., Weisenberger, D. J., Li, M., Zhou, W., Peng, C.-C., Stachelek, K., Cobrinik, D., Liang, G. & Berry, J. L. Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy. Nat Commun 13, 5523 (2022).

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2022

Cambier, L., Stachelek, K., Triska, M., Jubran, R., Huang, M., Li, W., Zhang, J., Li, J. & Cobrinik, D. Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers. Sci Rep 11, 94 (2021).

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2021

Kaneva, K., Merkurjev, D., Ostrow, D., Ryutov, A., Triska, P., Stachelek, K., Cobrinik, D., Biegel, J. A. & Gai, X. Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods. Mitochondrion 51, 97–103 (2020).

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2020

Berry, J. L., Xu, L., Kooi, I., Murphree, A. L., Prabakar, R. K., Reid, M., Stachelek, K., Le, B. H. A., Welter, L., Reiser, B. J., Chévez-Barrios, P., Jubran, R., Lee, T. C., Kim, J. W., Kuhn, P., Cobrinik, D. & Hicks, J. Genomic cfDNA analysis of aqueous humor in retinoblastoma predicts eye salvage: the surrogate tumor biopsy for retinoblastoma. Molecular Cancer Research 16, 1701–1712 (2018).

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2018

Singh, H. P., Wang, S., Stachelek, K., Lee, S., Reid, M. W., Thornton, M. E., Craft, C. M., Grubbs, B. H. & Cobrinik, D. Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. PNAS 115, E9391–E9400 (2018).

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2018

Kim, J. W., Jacobsen, B., Zolfaghari, E., Ferrario, A., Chevez-Barrios, P., Berry, J. L., Lee, D. K., Rico, G., Madi, I., Rao, N., Stachelek, K., Wang, L.-C. & Gomer, C. Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft. Graefe’s Archive for Clinical and Experimental Ophthalmology 255, (2017).

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2017

Berry, J. L., Xu, L., Murphree, A. L., Krishnan, S., Stachelek, K., Zolfaghari, E., McGovern, K., Lee, T. C., Carlsson, A., Kuhn, P., Kim, J. W., Cobrinik, D. & Hicks, J. Potential of aqueous humor as a surrogate tumor biopsy for retinoblastoma. JAMA Ophthalmology 135, 1221–1230 (2017).

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2017

Stachelek, K., Harutyunyan, N., Lee, S., Harutyunyan, A., Kim, J., Xu, L., Berry, J. L., Nagiel, A., Reynolds, C. P., Murphree, A. L., Lee, T. C., Aparicio, J. G. & Cobrinik, D. Non-Synonymous, synonymous, and non-coding nucleotide variants contribute to recurrently altered biological processes during retinoblastoma progression. Submitted.

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2022

Shayler, D., Stachelek, K., Lee, S., Bai, J., Aparicio, J. G., Kim, Y., Singh, M., Bay, M., Thornton, M., Craft, C., Grubbs, B., Bonaguidi, M., Singh, H., & Cobrinik, David. Single cell transcriptomics reveals novel photoreceptor trajectories and a cancer-predisposed cone precursor state.

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2022

Refereed Presentations

Children’s Blood Disease Institute Annual Retreat 2022

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2022

Biochemistry and Molecular Medicine Annual Retreat 2022

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2022

The Saban Research Institute Science Day 2022

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2022

Keystone Symposium 2019

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2019

Software & Technology

SeuratTools

hideme

2022

Teaching

Introduction to R: Workshop for incoming PhD students - University of Southern California

hideme

2022

  • Led, organized, and co-designed 3-day workshop

Introduction to R: Workshop for incoming PhD students - University of Southern California

hideme

2021

  • Led, organized, and co-designed 3-day workshop

Other Publications

Moving the retinoblastoma aqueous humor liquid biopsy beyond genomics

hideme

2022

  • “Behind the Paper” blog post to Nature Communities